The Pet Factory CareChewz Collagen 6-7″ Twist Keys Dog Chew Treats are made with premium ingredients that promote dental health and help reduce inflammation. These treats are perfect for dogs of all life stages, including puppies, adults, and seniors. The all-natural collagen is sourced from American-sourced beefhide, and the product is certified by the FDA. The Pet Factory CareChewz Collagen 6-7″ Twist Keys Dog Chew Treats are also made in our Global Food Safety Initiative-certified manufacturing facility, which gives customers peace of mind in knowing that our products are produced under optimum safety and quality conditions.